Protein Details: Two pore calcium channel protein 1

Protein ID

ICDB_Pro_1113

Protein Name

Two pore calcium channel protein 1

Gene Name

TPC1

Organism

Hordeum vulgare (Barley)

Length

742 amino acids

AlphaFoldDB

AF-Q6S5H8-F1-model_v4.pdb

Function

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca(2+) influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses (By similarity).

Sequence

MSEAQAPLITEEAAERGLASSGSRRLSDGGGGQGSRKYRRRSDALAHGDRYQKAAALVDLAEDGVGIPEDVLNDTRFGRAMSFYFVYLRLDWLWSLNIFALILLNFLEKPLWCRKDALHACDQRDMYFLGQLPYFSKTESLIYEGLTLVILVMEILCPLSYEGLNIFWRSTTNKLKILLLFILACDILVFAFSSQPFRLAPYIRVVFLIMTIRELRMCAITLAGLIGTYLNVLALSLLFLLFASWLAYVTFEDTPQGKTIFSSYGVTLYQMFVLFTTSNNPDVWVPAYKISRWYSLFFIVYVLLGVYFLTNLILAVIYDSFKEQFAKQLVQVDAIRKNILQKAFELIDTNTRGYLDREQCISLLNELNKYRSLPKTSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFPFYHSPVCGRLKSFVRSRTFEYIIVFVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWIYVAEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAFPSKLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRVFVATFFTLMSSLMPYLGIVFCILCMYCSLGLQIFGGIVYAGNPTLEETDLFSNDYLLFNFNDYPSGMVTLFNLLVMGNWQVWMESYWQLTGSSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQSPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNELDGSQNS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

RefSeq

Feature